ISO Mission Control J. Faelker, J. Casale M. ESA/ESOC Abstract: ESA's Infrared Space Observatory (ISO) is the first cryogenically cooled astronomical observatory and as such presents specific control requirements for spacecraft subsystems and instruments. The 18 months cryogen limited lifetime (now predicted for 24 months) and an oversubscription for astronomical observations demands rapid but safe execution of satellite and instrument operations. Telescope pointing requirements, higher than specified, instrument detectors whose performance is highly variable and susceptible to memory effects, short lifetime and satellite susceptibility to damage present conflicting requirements on the mission control system and complicate the data processing of the observations. These are described and lessons drawn which will be useful for the design of future "extreme" missions.